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Ohio State is creating a database for genetic research into Alzheimer’s disease

COLUMBUS, Ohio – Scientists at The Ohio State University Wexner Medical Center have created a searchable database to help advance research into Alzheimer’s disease, the most common form of dementia.

The database, known as ssREAD, is free to any researcher studying the pathology of the disease. It contains information about changes in gene expression that are thought to underlie the brain degeneration that occurs as a result of the disease.

“These technologies have shed new light on the exploration of Alzheimer’s disease pathogenesis and sex differences at the cellular and molecular levels,” said co-author Hongjun “Harry” Fu, assistant professor of neuroscience at Ohio State. “Our ssREAD repository provides a broader spectrum of data sets related to Alzheimer’s disease, with an optimized analytical pipeline and improved usability,”

Medical examination

The database contains almost 300 datasets from 67 different studies, covering more than 7 million cells. The repository also contains nearly 400 samples of gene expression profiles from 85 studies in humans and mice.

Details about the dataset are outlined in a manuscript published online in Nature Communications.

“We are closing the gap for researchers by creating this specialized database,” said Qin Ma, professor in Ohio State’s department of biomedical informatics. “Integrating these diverse data sets and conditions will be invaluable to researchers studying the complex landscape of Alzheimer’s disease.”

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